The changes of laboratory indexes in children with hepatoblastoma between pre-treatment and post-treatment with pirarubicin chemotherapy

Abstract

Objective To investigate the laboratory indexes changes of cardiotoxicity before and after pirarubicin(THP)chemotherapy in children with hepatoblastoma(HB). Methods The clinical data of 76 cases were collected whose were postoperative HB children and were given THP chemotherapy from January 2012 to June 2015 in our hospital.Changes of serum laboratory indexes including N-terminal pro-brain natriuretic peptide(NT-proBNP)and creatine kinase isoenzymes(CKMB)were analyzed by statistical methods between pre-treatment and post-treatment with THP. Results There was no definite cardiotoxicity case in 76 children with HB.The serum NT-proBNP level of pre-treatment was(80.93±74.13)ng/L and the level of post-treatment was(211.85±211.42)ng/L.The changes of serum NT-proBNP showed statistical difference(P=0.00, P 0.05). The pre-treatment level of CKMB was(23.08±13.52)U/L and post-treatment level was(30.90±13.92)U/L.The changes of serum CKMB level showed statistically difference(P=0.00, P<0.05). Conclusion The serum NT-proBNP level of postoperative HB was significantly increased after given THP chemotherapy, which might have a certain clinical significance for early monitoring of cardiotoxicity. Key words: Cardiotoxicity; NT-proBNP; CKMB; Hepatoblastoma