Abstract
A method is described for the measurement of the rate of inspiratory mechanical work in unanæsthetized normal men. The changes in ventilation and inspiratory work rate produced by the inhalation of various concentrations of CO2 and O2 are described in seven normal male subjects, aged 25–60. These changes are related to the levels of arterial PCOCO2, POO2, and pH.The rate of inspiratory work is found to be proportional to the logarithm of the ventilation, with an exponent of 1·79, and the implication of this result is discussed. The relationship between ventilation and Pco, is discussed in terms of the e(uation V=S(PCOCO2‐B). The tendency to develop a metabolic acidosis during CO2 inhalation is not fotmd to be significant in the present data.
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