Abstract
Objective To explore the cognitive dysfunction and the related neurobiological basis in alcohol dependence.Methods The patients with alcohol dependence and 10 healthy persons were involved.The proton magnetic resonance spectroscopy were used to determine absolute concentrations of N-acetylaspartate(NAA),creatine(Cr),and Choline(Cho)in white and gray matter of the frontal lobe,and cognitive function Was measured with the Wisconsin card sorting test. The patients were examined twice,I.e..when they kept drinking and after 1 month withdrawal.Results The pre-withdrawal NAA/Cr ratio in patient was significanfly lower than that in controls(left white matter:1.45±0.38 vs.2.16±0.40:left gray matter:1.17±0.11 vs.1.67±0.33;right white matter:1.59±0.25 vs.2.09±0.41;right gray matter:1.44±0.40 vs.1.56±0.30;all P＜0.05).After 1 month abstinence,the change of NAA/Cr ratio in right gray matter was significantly correlated to the neuropsychological improvement.Conclusions Alcohol dependence may induce specific metabolic changes in frontal lobe,which may be related to cognitive impairment in patients with alcohol dependence. Key words: Alcohol-related disorders; Cognition disorders; Magnetic resonance spectroscopy
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