The changes in expression of high-sensitivity C-reactive protein, glutathione S-transferase Pi and annexin A5 in elderly patients with old myocardial infarction and the clinical significance

Abstract

Objective To study the changes in expression of high-sensitivity C-reactive protein(hs-CRP), glutathione S-transferase Pi(GSTPi)and annexin A5(AnxA5)in elderly patients with old myocardial infarction and the clinical significance. Methods Serum levels of GSTPi and AnxA5 were measured by ELISA and the level of hs-CRP was measured by immunoturbidimetry in elderly patients with old myocardial infarction(n=185)from December 2012 to November 2015. Results Along with the increasing coronary artery stenosis, GSTPi level was decreased and AnxA5/hs-CRP levels were increased in elderly patients with old myocardial infarction.In comparison between coronary artery stenosis >95% group versus stenosis of 55%-65% group, GSTPi was(190.0±37.0)μg/L vs.(289.0±86.0)μg/L, AnxA5 was(33.9±4.0)μg/L vs.(8.1±2.9)μg/L, and hs-CRP was(15.3±1.3)mg/L vs.(5.9±0.8)mg/L with statistically significant differences(all P<0.01). There were significant differences between LVEF 30% group〔GSTPi(198.0±39.0)μg/L, AnxA5(38.9±5.1)μg/L and hs-CRP(17.9±1.9)mg/L〕and LVEF 40%-54% group〔GSTPi(219.0±61.0)μg/L, AnxA5(12.9±3.9)μg/L and hs-CRP(10.1±1.0)mg/L〕(all P<0.01). There were significant differences between NYHA Ⅳ group〔GSTPi(171.0±43.0)μg/L, AnxA5(18.1±5.0)μg/L and hs-CRP(16.9±2.1)mg/L〕and NYHAⅠgroup〔GSTPi(295.0±91.0)μg/L, AnxA5(7.3±3.1)μg/L and hs-CRP(7.8±1.3)mg/L〕(all P<0.01). Conclusions The expression of GSTPi, AnxA5 and hs-CRP in elderly patients with old myocardial infarction may become the new indicators to forecast the degrees of coronary artery stenosis and heart failure. Key words: Glutathione S-transferase pi; Annexin A5; C-reactive protein; Myocardial infarction