Abstract
ABSTRACTObjectives The aim of this prospective clinical study was to investigate variations in a novel oxidative stress marker (thiol/disulphide homeostasis) in men who underwent transrectal ultrasound guided prostate biopsy (TRUSB).Materials and Methods A total of 22 men undergoing TRUSB of the prostate were enrolled in the study. Patients with abnormal digital rectal examination and/or total prostate specific antigen (PSA) over 4ng/mL underwent TRUSB with 12 cores. Serum samples were obtained before and just after the procedure to evaluate the possible changes in thiol/disulphide homeostasis. Mean age, total PSA and free PSA, prostate volume and histopathological data were also recorded.Results Mean age of the study population was 65.05±8.89 years. Significant decreases in native and total thiol levels were documented after the biopsy procedure. However, serum disulphide levels and disulphide/native thiol, disulphide/total thiol and native/total thiol ratios did not significantly change after TRUSB. No correlation was observed between oxidative parameters and total PSA and free PSA levels, prostate volume and histopathology of the prostate. However, mean patient age was significantly correlated with mean native and total thiol levels.Conclusion Significant decreases in serum native and total thiol levels related to the prostate biopsy procedure suggest that TRUSB causes acute oxidative stress in the human body. Since our trial is the first in the current literature to investigate these oxidative stress markers in urology practice, additional studies are warranted.
Highlights
Prostate cancer is a major health problem globally and the incidence is rising
We investigated the changes in dynamic thiol/disulphide homeostatic state in men undergoing transrectal ultrasound guided prostate biopsy (TRUSB) for abnormal digital examination or serum total prostate specific antigen (PSA) elevation
Mean serum total PSA and free PSA levels, prostate volume and histopathological results of biopsy specimens of all patients are given in Table-1
Summary
After the entry into health care the use of conventional ultrasounds, Watanabe et al described the first transrectal ultrasonography in 1967 [1]. During the ‘80s, transrectal ultrasound guided prostate biopsy (TRUSB) became a primary technique for the detection of prostate cancer. Routine 12-core (extended) biopsy ibju | Thiol/Disulphide homeostasis change after ultrasound guided prostate biopsy is recommended as an office-based, diagnostic standard for evaluating patients with increasing PSA levels [5]. TRUSB is an invasive technique and, rare, may be associated with complications such as acute prostatitis, hematuria and rectal bleeding. As such, it exerts stress on the human body
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