The change in one-hour postload plasma glucose levels, and an analysis of its related factors in abdominally obese Han Chinese men with normal glucose tolerance

Abstract

ObjectiveThis study was to observe the difference in one-hour postload plasma glucose levels and analyze its related factors in abdominally obese men with normal glucose tolerance (NGT). DesignThis case–control study included 36 abdominally obese men (waist circumference≥90cm) and 31 non-abdominally obese men (waist circumference<90cm) aged 20–50years with NGT. Cases and controls were matched in age. All subjects underwent oral glucose tolerance test with 75g of oral anhydrous glucose. Results0.5 and 1-h postload plasma glucose levels were higher in abdominally obese group than in non-abdominally obese group (P<.05). Fasting plasma glucose (FPG), 2 and 3-h postload plasma glucose were similar in the two groups (P>.05). 1-h postload plasma glucose was positively correlated with body mass index (r=0.454), waist circumference(WC) (r=0.519), systolic blood pressure (r=0.456), diastolic blood pressure (r=0.338), triglycerides (r=0.439), and negatively correlated with high density lipoprotein cholesterol (r=−0.391), 1/fasting insulin (r=−0.459), insulinogenic index (r=−0.357) and disposition index (r=−0.602) (P<.01). In multiple regression analysis, 1-h postload plasma glucose maintained an independent association with disposition index (β=−1.367, P=.000), WC (β=0.103, P=.000) and triglycerides (β=0.185, P=.017). ConclusionsThe present study demonstrated that the level of one-hour postload plasma glucose was elevated in abdominally obese men with NGT. Besides FPG and 2-h postload plasma glucose, we must also pay attention to the measurement of one-hour postload plasma glucose. Disposition index, WC and triglycerides were independently related factors for elevated one-hour postload plasma glucose.