Abstract
The change in physical character of the wall of the cervix has been investigated in sheep and goats in relation to the induction of parturition. Two types of observation were made, extension of isolated tissue in vitro and dilation of the cervical canal with balloons in vivo. A decrease in the elastance of the tissue was detectable within 12 hours of first administration of dexamethasone and the decrease was progressive thereafter. This change was unrelated to the plasma concentration of prostaglandins F. There was some relationship in time to changes in circulating concentrations of oestrogen and progesterone but this was not consistent in all animals. Biochemical investigations of cervical wall revealed a marked increase in the liberation of hydroxyproline from collagen and a change in the pattern of extractable glycosaminoglycans, as induction advanced.
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