Abstract
The cerebellum: from development to structural complexity and motor learning.
Highlights
The cerebellum coordinates motor activities to be performed or that are already underway
Complexity derived from experimental embryology approaches revealed a heterogeneous origin of cerebellar precursors, from at least three different domains: caudal mesencephalon, isthmus and rhombencephalon
We have strongly advanced in identifying the molecular mechanisms underlying internal cerebellar regionalization
Summary
The cerebellum coordinates motor activities to be performed or that are already underway. In parallel to the knowledge deficits on cerebellar function, cerebellar morphogenesis, which seems to be simple due to the repetitive myelo- and cyto-architecture along the whole organ, has revealed in the last two decades inspected complexities. First by the discovering of molecular heterogeneities in Purkinje cells; that is, new antigens (among zebrins were pioneers) revealed a repetitive-stripe like structural organization of cerebellar Purkinje cells that reminded sagittal distribution of cortical afferences and efferences in the cerebellum.
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