The Central Roles of Noncoding RNA in Estrogen-Dependent Female Reproductive System Tumors.

Jiajie Tu,Zhiying Yu,Lei Li,He Chen,Zhe Li,Xiaochun Chen,Yu Chen,Yu Chen Yu Chen,Huan Yang,Lei Jiang,Yuanyuan Zhang,Alexander Schreiber

doi:10.1155/2021/5572063

Abstract

The pathogenesis of ovarian and endometrial cancers is closely associated with estrogen-related pathways. These estrogen-dependent tumors seriously threaten the health and quality of life in women. Noncoding RNAs (ncRNAs) are defined as RNAs that do not encode proteins, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), both of which have been reported in estrogen-dependent female reproductive system tumors. This review systematically summarizes the role of ncRNAs in estrogen-dependent tumors and common patterns of regulatory mechanisms to explore their future research directions in tumor diagnosis, treatment, and prognosis. This may provide new ideas for the potential application of ncRNAs in estrogen-dependent female reproductive system tumors.

Highlights

Estrogen is closely related to the occurrence and development of reproductive system tumors in women, such as ovarian and endometrial cancers, which are important causes of morbidity and mortality [1]
Emerging research has demonstrated that ncRNAs are abnormally expressed and play an important role in estrogendependent female reproductive system tumors, but most are individual studies in a particular type of tumor. erefore, we summarize the relevant literature to review the role and compare the common regulatory pattern of ncRNAs in estrogen-dependent female reproductive system tumors
Knowledge of these estrogen-regulated long noncoding RNAs (lncRNAs) could help our understanding of the estrogenic effect on ovarian cancer and may assist in the clinical design of new target therapies based on lncRNA [15]

Summary

Review Article

The Central Roles of Noncoding RNA in Estrogen-Dependent Female Reproductive System Tumors. Jiajie Tu ,1,2 Huan Yang ,2 Lei Jiang ,1 Yu Chen ,3 Yu Chen ,2 Zhe Li ,4 Lei Li ,2 Yuanyuan Zhang ,2 Xiaochun Chen ,2 He Chen ,2 and Zhiying Yu 2. E pathogenesis of ovarian and endometrial cancers is closely associated with estrogen-related pathways. Ese estrogendependent tumors seriously threaten the health and quality of life in women. Noncoding RNAs (ncRNAs) are defined as RNAs that do not encode proteins, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), both of which have been reported in estrogen-dependent female reproductive system tumors. Is review systematically summarizes the role of ncRNAs in estrogen-dependent tumors and common patterns of regulatory mechanisms to explore their future research directions in tumor diagnosis, treatment, and prognosis. Is may provide new ideas for the potential application of ncRNAs in estrogen-dependent female reproductive system tumors Noncoding RNAs (ncRNAs) are defined as RNAs that do not encode proteins, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), both of which have been reported in estrogen-dependent female reproductive system tumors. is review systematically summarizes the role of ncRNAs in estrogen-dependent tumors and common patterns of regulatory mechanisms to explore their future research directions in tumor diagnosis, treatment, and prognosis. is may provide new ideas for the potential application of ncRNAs in estrogen-dependent female reproductive system tumors

Introduction

Cell proliferation and invasion

Cell viability Proliferation and invasion

Findings

Proliferation and migration