Abstract
Lung cancer is one of the most common types of cancer in the world. Although the mechanism of lung cancer is still unknown, a large number of studies have found a link between gene polymorphisms and the risk of lung cancer. The tumor suppressor p53 plays a crucial role in maintaining genomic stability and tumor prevention. MDM2 is a critical regulator of the p53 protein. Despite the importance of p53 pathway in cancer, data on the contribution of SNPs of TP53 (rs1042522) and MDM2 (rs2279744) to the development of lung cancer are very contradictory. A metaanalysis that collects quantitative data from individual studies and combines their results has the advantage of improving accuracy, providing reliable estimates, and resolving those issues in which studies on individual associations are not effective enough. The aim of this study was to determine whether the TP53 (rs1042522) and MDM2 (rs2279744) polymorphisms confer susceptibility to lung cancer. A meta-analysis was conducted on the associations between the TP53 (rs1042522) and MDM2 (rs2279744) polymorphisms and lung cancer. A total of 51 comparison studies including 25,366 patients and 25,239 controls were considered in this meta-analysis. The meta-analysis showed no association between lung cancer and MDM2 (rs2279744) under any model. A noteworthy association of TP53 (rs1042522) with susceptibility to lung cancer in overall pooled subjects was observed under three different models (allele contrast, homozygote contrast (additive) and dominant). Stratification by ethnicity indicated an association between the TP53 (rs1042522) and lung cancer in Asians and Caucasians. This meta-analysis demonstrates that the TP53 (rs1042522), but not MDM2 (rs2279744) polymorphism may confer susceptibility to lung cancer.
Highlights
Introduction cancer inGerman residents (Popanda et al, 2007), and lung adenocarcinoma in the Chinese population (Zhang X. et al., 2006; Ren et al, 2013).Data on the contribution of MDM2 SNP309 to the development of lung cancer are very contradictory
This meta-analysis demonstrates that the TP53, but not MDM2 polymorphism may confer susceptibility to lung cancer
The search strategy was performed using a combination of the following keywords: “TP53”, “Murine double minute 2” or “MDM2”, “polymorphism”, “SNP”, “rs1042522”, “rs2279744”, “Arg72Pro”, “codon 72 Arg”, “c.215C > G”, “SNP309”, “c.291 T > G” “lung cancer”, “non-small cell lung cancer”, “association”
Summary
German residents (Popanda et al, 2007), and lung adenocarcinoma in the Chinese population (Zhang X. et al., 2006; Ren et al, 2013). Data on the contribution of MDM2 SNP309 to the development of lung cancer are very contradictory. Most studies have shown an association of the MDM2 (rs2279744) mutant allele with a high risk of lung tissue carcinogenesis (Enokida et al., 2014; Wang X. et al, 2015; Li, 2017). (2006) did not find that MDM2 SNP309 is associated with lung neoplasia in the European population. The data on the association of polymorphisms of the TP53 genes Arg72Pro (rs1042522) and MDM2 SNP309 (rs2279744). With the development of tumors as a whole are very contradictory. It would be interesting to perform a metaanalysis on the association of TP53 Arg72Pro (rs1042522)
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