Abstract
cdc25C is a dual specificity phosphatase essential for the dephosphorylation and activation of cyclin dependent kinase 1 (cdk 1) a prerequisite step for mitosis in all eucaryotic organisms. In order to activate cdk1, human cdc25C is phosphorylated on at least 6 sites of which serine 214 is associated with the active form of cdc25C. In normal mitosis, the phosphorylation on serine 214 is essential to transit metaphase to anaphase and its inhibition blochs cells in metaphase. Here, we have investigated if phosphorylation of cdc25C serine 214 is required and plays a role in modulating cdk1 activation during human meiosis.
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