Abstract
The Cell and Molecular Biology of Neurodegenerative Diseases: An Overview
Highlights
Throughout this topic, it becomes evident that there are common cellular pathways that are altered in these disorders, including protein, mitochondrial, and transcriptional homeostasis
Kerrigan and Randall (1) discuss how alterations of Arc protein in the brains of Alzheimer’s disease (AD) patients and animal models of AD may be a clue as to how synaptic transmission is altered in AD, and how this cellular pathway may be of interest for therapeutic development
Almeida et al (5) provide a structural and functional view of trinucleotide repeats and encoded homopeptide expansions, emphasizing polyQ expansions and their role in inducing the self-assembly, aggregation, and functional alterations of the protein, leading to neuronal toxicity and cell death. These authors focus on ataxin-3 and huntingtin (Htt), the main protein implicated in Machado– Joseph Disease (MJD) and Huntington’s disease (HD) respectively
Summary
Throughout this topic, it becomes evident that there are common cellular pathways that are altered in these disorders, including protein, mitochondrial, and transcriptional homeostasis. Kerrigan and Randall (1) discuss how alterations of Arc protein in the brains of AD patients and animal models of AD may be a clue as to how synaptic transmission is altered in AD, and how this cellular pathway may be of interest for therapeutic development. The three reviews discuss the molecular events underlying PD and how the normal function of specific proteins associated with PD can help shed light on the causes of familial and sporadic PD.
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