Abstract
We investigated the circulating cytotoxic CD160 + CD8 high subset in correlation to antiviral immunity and response to highly active antiretroviral therapy (HAART) in HIV+ subjects. The study included 45 treatment-naive patients receiving HAART for 18 months, retrospectively defined as good ( n = 29) and transient ( n = 16) responders. HIV-specific CD8 T lymphocyte levels were measured by IFNγ production in response to p17 Gag, in the presence of immobilized anti-CD160 mAb. We report a significantly increased baseline level of CD160 + CD8 high subset in good therapy responders. CD160 + CD8 high subset correlates with CD4 + T cell count, immune activation, and viral load. CD160 + CD8 high lymphocytes contain a high amount of Granzyme B and include virus-specific T lymphocytes in HIV-1+ subjects. Co-stimulation through CD160 molecules enhances IFNγ production in response to p17 Gag. Therefore, the CD160 + CD8 high subset may be useful for monitoring of virus-specific cellular immunity and predicting response to antiretroviral therapy in chronic HIV-1 infection.
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