Abstract
OR=1.177, 95%CI=1.066-1.301, p=0.001). However, there was no association between the CCND1 G870A polymorphism and leukemia risk. In conclusion, the CCND1 G870A polymorphism may increase risk of non-Hodgkin lymphoma, but not leukemia. However, more primary large scale and well-designed studies are still required to evaluate the interaction of CCND1 G870A polymorphism with leukemia and non-Hodgkin lymphoma risk.
Highlights
Leukemia and non-Hodgkin lymphoma have been selected in our study because of their high incidence rates and mortality rates
Inclusion and Exclusion Criteria Studies included in the meta-analysis must meet the following criteria: they (a) evaluated the association between CCND1 G870A polymorphism and leukemia or non-Hodgkin lymphoma risk; (b) supplied the number of individual genotypes for the CCND1 G870A gene polymorphisms in leukemia or non-Hodgkin lymphoma cases and controls, respectively; and (c) were case-control studies
Data extraction From each eligible study, the following information were extracted by two investigators independently with the standard protocol: the first author’s surname, year of publication, country of origin, ethnicity, tumor type, source of control, method of genotyping, numbers of cases and controls, Hardy-Weinberg equilibrium (HWE) of controls, and the frequency of genotypes in both cases and controls
Summary
Leukemia and non-Hodgkin lymphoma have been selected in our study because of their high incidence rates and mortality rates. According to the degree of cell differentiation and the length of the natural course of the disease, leukemia is classified as acute leukemia and chronic leukemia in general. Acute leukemia is a malignant tumor of the hematopoietic system. ALL, with a high degree of malignancy, recurrence rate, poor prognosis features and multiple drug resistance, is a greater difficulty in its treatment. ALL is the most common diseases of children malignant tumor (Advani et al, 2009; Stieglitz et al, 2013). NonHodgkin lymphoma (NHL), a heterogeneous disease, results from the malignant transformation of lymphocytes and contains multiple subtypes, each with specific molecular and clinical characteristics. The etiology of NHL, which includes many factors, environmental factors and genetic factors, is not clear (Morton et al, 2008; Bassig et al, 2012)
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