Abstract
Immunosuppressive cells have been highlighted in research due to their roles in tumor progression and treatment failure. Myeloid-derived suppressor cells (MDSCs) are among the major immunosuppressive cell populations in the tumor microenvironment, and transcription factors (TFs) are likely involved in MDSC expansion and activation. As key regulatory TFs, members of the CCAAT/enhancer-binding protein (C/EBP) family possibly modulate many biological processes, including cell growth, differentiation, metabolism, and death. Current evidence suggests that C/EBPs maintain critical regulation of MDSCs and are involved in the differentiation and function of MDSCs within the tumor microenvironment. To better understand the MDSC-associated transcriptional network and identify new therapy targets, we herein review recent findings about the C/EBP family regarding their participation in the expansion and function of MDSCs.
Highlights
In the tumor microenvironment, immunosuppressive cells function to inhibit tumor immune responses and promote tumor immune evasion
CCAAT/enhancer-binding protein (C/EBP) can interact with other transcription factors (TFs) or proteins such as Rb, E2F, PU.1, runt-related transcription factor (Runx) proteins, p300/CREB-binding protein (CBP), and death-associated protein 6 (Daxx) in distinct cells [19], though whether the interaction exists in Myeloid-derived suppressor cells (MDSCs) remains to be further investigated
It is evident that C/EBP family members control the expansion and functional features of MDSCs
Summary
Protein Family: Its Roles in MDSC Expansion and Function. Immunosuppressive cells have been highlighted in research due to their roles in tumor progression and treatment failure. Myeloid-derived suppressor cells (MDSCs) are among the major immunosuppressive cell populations in the tumor microenvironment, and transcription factors (TFs) are likely involved in MDSC expansion and activation. As key regulatory TFs, members of the CCAAT/enhancer-binding protein (C/EBP) family possibly modulate many biological processes, including cell growth, differentiation, metabolism, and death. Current evidence suggests that C/EBPs maintain critical regulation of MDSCs and are involved in the differentiation and function of MDSCs within the tumor microenvironment. To better understand the MDSC-associated transcriptional network and identify new therapy targets, we review recent findings about the C/EBP family regarding their participation in the expansion and function of MDSCs
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