Abstract
Methods 233 T2DM patients with MCI or without MCI were recruited. Baseline data and genotype frequency were compared between MCI and non-MCI groups. Demographic parameters and neuropsychological tests results were analyzed among patients with different genotypes. Further correlation and regression analysis were conducted to find the association between cognition and cholesterol. Results Despite no significant statistical difference was detected, we observed higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL) in patients with MCI than those without MCI. In addition, we observed higher TC and LDL levels in patients with GG or GC genotypes than those with CC genotype (P < 0.001, P = 0.004, or P < 0.001, P = 0.002). Interestingly, increased MoCA and decreased TMTB scores were found in patients with CC genotype, compared to those with GG or CG genotype (P = 0.009, P = 0.024, or P = 0.005, P = 0.109). Moreover, partial correlation (P = 0.030 and P = 0.004, respectively) and multiple linear regression (P = 0.030 and P = 0.005, respectively) showed that TC and LDL levels are associated with the TMTB score, indicating the executive function. Conclusions CC genotype of INSIG-2 rs7566605 may be a protective factor of hypercholesteremia susceptible to MCI, especially to the executive function of T2DM. This trial is registered with ChiCTROCC15006060.
Highlights
The prevalence of type 2 diabetes mellitus among adults has increased to 10.4% and affected 300 million worldwide [1]
There was no association found between genotype at rs7566605 and obesity-related phenotypes in this British Caucasian population [15], the promoter of Insulin-induced gene 2 (INSIG-2) rs7566605 single-nucleotide polymorphism (SNP) is associated with the prevalence of hypercholesterolemia [16]
There was no significant difference of genotype distribution in type 2 diabetes mellitus (T2DM) patients with or without mild cognitive impairment (MCI), we found difference of metformin use frequencies, total cholesterol (TC), low-density lipoprotein cholesterol (LDL), and ApoB levels, as well as Montreal Cognitive Assessment (MoCA) score and Trail Making Test-B (TMTB) score (Table 3, all P < 0:05 ), indicating the executive function
Summary
The prevalence of type 2 diabetes mellitus among adults has increased to 10.4% and affected 300 million worldwide [1]. Diabetes increased about 50% risk of Alzheimer’s disease (AD) [2] with a prodromal stage called MCI, a transitional stage between normal cognition and AD dementia [3]. Previous researches suggested that uncontrolled hyperglycemia is a risk factor of T2DM with MCI [4, 5]. Epidemiological evidence showed that cholesterol is a risk factor for AD [6]. Our recent study demonstrated that poorly controlled cholesterol is associated with cognitive impairment in T2DM human [8]. Increased LDL cholesterol caused cognitive decline in LDL-/- mice [9]. We guess that the reason causing hypercholesterolemia may result in cognitive impairment
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
