THE CAUSES OF SECONDARY FEVER IN SULFAPYRIDINE-TREATED PNEUMONIA

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Article1 April 1941THE CAUSES OF SECONDARY FEVER IN SULFAPYRIDINE-TREATED PNEUMONIAHARRY F. DOWLING, M.D., THEODORE J. ABERNETHY, M.D.HARRY F. DOWLING, M.D.Search for more papers by this author, THEODORE J. ABERNETHY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-10-1815 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe beneficial effect of sulfapyridine on the course and outcome of most cases of pneumococcus pneumonia has now been definitely established. A more or less rapid drop in temperature, followed by gradual disappearance of toxicity, may be expected. The temperature usually remains at normal or nearly normal levels, and the patient recovers completely. In a small but definite group of cases, however, the temperature rises again, with the accompaniment of some degree of toxicity. In our experience such a phenomenon is more frequent in sulfapyridine-treated patients than in patients recovering spontaneously or after treatment with specific serum. When such a...Bibliography1. HAGEMANBLAKE POFG: A specific febrile reaction to sulfanilamide. Drug fever, Jr. Am. Med. Assoc., 1937, cix, 642. CrossrefGoogle Scholar2. BROWNTHORNTONWILSON WHWBJS: An evaluation of the clinical toxicity of sulfanilamide and sulfapyridine, Jr. Am. Med. Assoc., 1940, cxiv, 1605. Google Scholar3. FINLANDWINKLER MAW: Recurrences in pneumococcus pneumonia, Am. Jr. Med. Sci., 1934, clxxxviii, 309. CrossrefGoogle Scholar4. HAMBURGERRUEGSEGGER MJM: Early recurrence of sulfapyridine-treated Type I pneumococcal pneumonia, New England Jr. Med., 1939, cci, 445. CrossrefGoogle Scholar5. FINLANDSPRINGLOWELL MWCFC: Immunological studies on patients with pneumococcic pneumonia treated with sulfapyridine, Jr. Clin. Invest., 1940, xix, 179. CrossrefGoogle Scholar6. KNEELANDMULLIKEN YB: Antibody formation in cases of lobar pneumonia treated with sulfapyridine, Jr. Clin. Invest., 1940, xix, 307. CrossrefGoogle Scholar7. WOODLONG WBPH: Observations upon the experimental and clinical use of sulfapyridine. III. The mechanism of recovery from pneumococcal pneumonia in patients treated with sulfapyridine, ANN. INT. MED., 1939, xiii, 612. Google Scholar8. COGGESHALLROBERTSON LTOH: A study of repeated attacks of experimental pneumococcus lobar pneumonia in dogs, Jr. Exper. Med., 1935, lxi, 213. CrossrefGoogle Scholar9. ROBERTSONLOOSLI OHCG: A study of the macrophage reaction in the pulmonary lesions of dogs with experimental pneumococcus pneumonia, Jr. Exper. Med., 1938, lxvii, 575. CrossrefGoogle Scholar10. ROBERTSONUHLEY OHCG: Changes occurring in the macrophage system of the lungs in pneumococcus lobar pneumonia, Jr. Clin. Invest., 1936, xv, 115. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication June 21, 1940.From the Health Department, District of Columbia, the Department of Medicine, George Washington University School of Medicine, and the Parmelee Pneumonia Research Laboratory, Emergency Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKlinische Ergebnisse der Chemotherapie durch Sulfonamide 1 April 1941Volume 14, Issue 10Page: 1815-1826KeywordsFeversHospital medicinePneumococcusPneumoniaResearch laboratoriesTemperatureToxicity ePublished: 1 December 2008 Issue Published: 1 April 1941 PDF downloadLoading ...