The causal effect of atopic dermatitis on lung cancer: A Mendelian randomization study.

Abstract

Growing evidence has shown that atopic dermatitis (AD) may decrease lung cancer (LC) risk. However, the causality between the two diseases is inconsistent and controversial. Therefore, we explored the causal relationship between AD and different histological subtypes of LC by using the Mendelian randomization (MR) method. We conducted the MR study based on summary statistics from the genome-wide association studies (GWAS) of AD (10,788 cases and 30,047 controls) and LC (29,266 cases and 56,450 controls). Instrumental variables (IVs) were obtained after removing SNPs associated with potential confounders. We employed inverse-variance weighted (IVW), MR-Egger, and weighted median methods to pool estimates, and performed a comprehensive sensitivity analysis. The results of the IVW method suggested that AD may decrease the risk of developing lung adenocarcinoma (LUAD) (OR=0.91, 95% CI: 0.85-0.97, P=0.007). Moreover, no causality was identified between AD and overall LC (OR=0.96, 95% CI: 0.91-1.01, P=0.101), lung squamous cell carcinoma (LUSC) (OR=1.04, 95% CI: 0.96-1.036, P=0.324), and small cell lung carcinoma (SCLC) (OR=0.95, 95% CI: 0.82-1.10, P=0.512). A comprehensive sensitivity test showed the robustness of our results. The present study indicates that AD may decrease the risk of LUAD in the European population, which needs additional investigations to identify the potential molecular mechanisms.