Abstract
Background: Catastrophization is a psychological aspect of pain that alters its perception and expression. Objective: Assess catastrophization in migraine. Design and setting: Cross-sectional observational study conducted by online survey, 2020. Method: Online survey of individuals suffering from migraine attacks at least twice a month, for at least one year. Confidentiality was assured. The participant gave details of his/her headache (including via a visual analogue pain scale) and answered the Hospital Anxiety and Depression Scale and the Catastrophization Scale questionnaires. Results: The survey identified 242 individuals with migraine attacks at least twice a month. The median scores observed in this group of individuals were 7 for pain, 11 for anxiety, 7 for depression and 2 for catastrophization. Catastrophization had no correlation with the duration or intensity of migraine pain. There was no correlation between catastrophization and headache frequency or the monthly amount of headache medication taken. High scores for catastrophization were identified in one third of the participants. High scores were not associated with age, headache duration, pain severity, frequency of attacks or traits of depression or anxiety. There was a moderate association between both depression and anxiety traits with catastrophization. Conclusion: Catastrophization seems to be a trait of the individual and appears to be unrelated to the characteristics of the migraine.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
Objectives: The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
The analyses showed significantly higher frequency of the genotype VV in those who had depression, compared with the allele A
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Neuroinfections are pathologies that affect the CNS, for example, we have Murcomycosis, a progressive infection caused by opportunistic fungi of the order Mucorales, with high frequency in Immunodepressed patients, Diabetes Mellitus (DM) is the main underlying pathology associated with the development of Rhinocerebral Murcomycosis, which represents 50% of the cases, with a mortality rate of 70% (Sidrim, 2012, p.168). The COVID-19 pandemic has been alarming the world since its first outbreak in December 2019 In this scenario, the presence of aggravating factors such as the elevation of the D-dimer and the reduction of the angiotensin-converting enzyme 2 (ACE2) during the clinical course of the disease, collaborated in the appearance of thromboembolic events derived from inflammatory processes and extensive intravascular coagulation, contributing to the emergence of diseases such as Hemorrhagic Stroke (ICH), leading the patient to have a worse clinical prognosis and a consecutive worsening of their health. Despite being classically associated with this etiology, the finding may be present in other diseases, especially infiltrative ones
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