Abstract
Because of an increasing interest in the effects of drugs and other chemicals on the eye, a study has been conducted on the cataractogenic activity of 2,4-dinitrophenol (DNP). Hitherto this effect of DNP has been considered to be specific for fowl and man only. The results reported here show that mature rabbits develop cataracts when DNP is instilled in the conjunctival sac or injected into the posterior chamber of the eye. Furthermore, lenses obtained from mature or immature rabbits, as well as ducks, develop cataracts when incubated in media containing DNP. In immature rabbits, cataracts develop following the intraperitoneal administration of DNP; the rabbit's susceptibility diminishes with age. It has been concluded that the apparent species specificity is related to a difference in the rate of clearance of DNP from the blood or to the presence of a blood-aqueous humor DNP barrier. The implications of these results in toxicologic investigations are discussed.
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