The catabolite gene activation system of E. coli may be directly involved in regulation of bacteriophage lambda development.

Abstract

The primary structure of bacteriophage lambda DNA has been searched for the presence of consensus CAP binding sites. Four putative CAP binding sites have been found on the lambda genome, indicating that the catabolite gene activation system of E. coli may be directly involved in the regulation of lambda development. Molecular mechanisms of putative cAMP-CAP-mediated stimulation of lysogenic and lytic responses are discussed.