Abstract
The Cat and Mouse of HIV-1 Antibody Escape
Highlights
Human immunodeficiency virus type 1 (HIV-1) is a chronically replicating lentivirus that must escape from adaptive immune responses that arise during the course of infection
The more recently performed studies used molecularly cloned envelope glycoprotein (Env)-pseudoviruses to more robustly study the plasma viral quasispecies at sequential time points. These data confirmed that, at any given time point during the course of HIV-1 infection, the circulating quasispecies of viral variants is resistant to the circulating plasma NAb
HIV-1 isolates that are resistant to circulating autologous NAbs generally remain sensitive to neutralization by several known monoclonal antibodies or by heterologous plasma obtained for other individuals with HIV-1
Summary
Human immunodeficiency virus type 1 (HIV-1) is a chronically replicating lentivirus that must escape from adaptive immune responses that arise during the course of infection. HIV-1 escape from autologous NAbs was first described in the early 1990s [18,19,20].
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