Abstract
The article concerns one of the common adverse effects during treatment — steroid myopathy. The information about pathogenic specifics of myopathy development in administration of glucocorticoids, the most typical clinical manifestations are described, and results diagnostic methods with estimation of a role of enzyme level evaluation, electromyography, ultrasound study of the muscle tissue, computer and magnetic resonance tomography. There is description of muscle weakness development in 49-year old woman who has been receiving methylprednisolone 88 mg/day due to revealed thrombocytopenia. One week after the treatment was started the patient experienced onset and progression of muscle weakness limiting her motion and self-maintenance. After performing of investigation including electromyography steroid genesis of myopathy was suggested. The patient’s condition began to improve after disc ontinuation of glucocorticoids and administration of calcium supplements, vitamin D, and anabolics, and the patient was discharged.
Highlights
For citation: Vatutin N.T., Ignatenko G.A., Taradin G.G. et al The Case of Acute Steroid-Induced Myopathy in the Patient with Autoimmune
The patient's condition began to improve after discontinuation of glucocorticoids and administration
Minetto M.A., Caresio C., Salvi M., et al Ultrasound-based detection of glucocorticoid-induced impairments of muscle mass and structure in Cushing’s disease
Summary
СЛУЧАЙ ОСТРОЙ СТЕРОИДИНДУЦИРОВАННОЙ МИОПАТИИ У ПАЦИЕНТКИ С АУТОИММУННОЙ ТРОМБОЦИТОПЕНИЕЙ. 1 — State Educational Organization of Higher Professional Education «M. Gorky Donetsk National Medical University», Donetsk, Ukraine 2 — State Institution «V.K. Gusak Institute of Urgent and Recovery Surgery», Donetsk, Ukraine 3 — Hospital of Republican Clinical Centre for Neurorehabilitation, Donetsk, Ukraine. Статья посвящена одному из частых побочных эффектов терапии глюкокортикоидов — стероидной миопатии. Приводятся сведения о патогенетических особенностях развития миопатии при применении глюкокортикоидов, описываются наиболее типичные клинические проявления, а также результаты диагностических методов с оценкой роли измерения уровней ферментов, электромиографии, ультразвукового исследования мышечной ткани, компьютерной и магнитно-резонансной томографии. Приводится описание развития мышечной слабости у 49-летней больной, которой в связи с выявленной первичной иммунной тромбоцитопенией был назначен метилпреднизолон в суточной дозировке 88 мг. После ряда выполненных исследований и, в частности, электромиографии, был предположен стероидный генез миопатии. Что данная работа, её тема, предмет и содержание не затрагивают конкурирующих интересов
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