Abstract
Phenyl diguanide has been described to cause, on intravenous injection, a reflex fall of blood pressure, bradycardia and apnoea by an action on sensory receptor in heart and lungs of cats. Dawes and Comroe (1954) proposed to describe these reflex effects as the coronary chemoreflex (Bezold-Jarisch effect), the pulmonary depressor chemoreflex and the pulmonary respiratory chemoreflex. Among these reflexes, the coronary chemoreflex has been extensively studied since the brilliant contribution by Bezold and Hirt (1867). There are, however, only a few reports on the pulmonary depressor or pulmonary respiratory chemoreflexes except those by Dawes et al.. In our laboratory, Takasaki (1956) clarified previously that the apnoea caused by intravenous injection of nicotine was due to the pulmonary respiratory chemoreflex, and furthermore the effects of several blocking agents on the reflex apnoea were reported in the other paper (Nakano et al., 1957). In the present experiments, the cardiovascular effects of phenyl diguanide have been reexamined and it comes to a somewhat different conclusion from those of Dawes and his coworkers, and the blocking actions of several drugs on the effects have been also studied.
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