Abstract
Ten patients were given 6 mg of pancuronium bromide intravenously, after a 20-minute period of mechanical ventilation with nitrous oxide:oxygen (4:2) and 0.5 per cent halothane. Cardiac output, mean arterial blood pressure, heart rate, central venous pressure, stroke volume, and total peripheral resistance were measured prior to administration and at 2, 5, and 10 minutes after injection of the drug. Cardiac output was increased relative to control during the post-injection study period (p < 0.001). On the average, heart rate increased, central venous pressure fell and mean arterial blood pressure rose slightly. Stroke volume and total peripheral resistance showed a variable response. We conclude that pancuronium bromide is compatible with nitrous oxide-halothane anaesthesia with respect to stability of the cardiovascular system.
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