Abstract
A pressurized aerosol isoproterenol sulfate was administered through a face mask or through an endotracheal tube to conscious beagle dogs. Tachycardia was elicited by both methods of dosing; however, depression of the ST segment of the EKG and arrhythmia was elicited only by the latter technique. Twenty to 80 sprays given endotracheally at the rate of 5 sprays per minute during inhalation on 2 consecutive days caused EKG changes and focal myocardial necrosis of dose-related severity. The left and right ventricular papillary muscles were the primary sites of the lesion. The presence of induced myocardial necrosis or ACTH pretreatment did not sensitize the heart to isoproterenol. Endotracheal dosing with such a product appears to be a suitable route for the detection of adverse cardiac effects in the dog.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
