Abstract
Electrocardiograms and myograms were recorded from isolated turtle hearts perfused with an extract from the roe of an alligator gar ( Lepisosteus spatula). Heart rate, S–T segment, systole, diastole, R, S and T wave amplitude were measured. The extract brought about a significant decrease ( P≤0·05) in amplitude of the EKG wave forms and in strength of contraction (g tension). Negative chronotropic (bradycardia, increase in duration of systole and diastole) and negative inotropic effects were observed. Changes in the T wave caused shortening of the S-T segment. The roe extract caused second degree atrioventricular block with the effects being dose related. High concentration of the extract caused cardiac arrest; the effects of smaller doses could be reversed. The extract may interfere with calcium ion permeability.
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