Abstract
SUMMARY The cardiorespiratory effects of intravenous infusions of isoprenaline (3 and 12 μg/min) were studied in eighteen mechanically ventilated dogs. Isoprenaline produced an increase in cardiac output, carbon dioxide output and oxygen consumption and a non-respiratory acidosis. In six dogs minute volume was kept constant so that arterial Pco2 increased. These dogs developed a marked increase in total venous admixture, most of which was due to an increase in ventilation/perfusion inequality, In tyhe remaining two groups of dogs arterial Pco2 was kept constant by increasing tital volume or respiratory frequency. Isoprenaline produced a smaller increase in total venous admixture in these dogs but the increase in right-to-left shunt was approximately the same in all three groups of dogs. In another six dogs the addition of carbon dioxide to the inspired gas produced no change in venous admixture.
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