Abstract
Using predictive computer software PASS, the antioxidant and cardioprotective properties of dimethyl-5-(bioguanide-1-il)isophthalate have been predicted. This substance was synthesized and tested in rats with experimental rheumatoid arthritis. We studied the indices of pathology progression, such as content of rheumatoid factor, erythrocyte sedimentation rate, contents of circulating immune complexes and immunoglobulins A, M, and G, activity of aspartate aminotransferase and myocardial creatine kinase, indices of intensity of free radical processes, including content of diene conjugates and activity of aconitase, and indices of apoptosis, such as activity of caspases, phosphatidylserine externalization, and DNA fragmentation. Administration of dimethyl-5-(bioguanide-1-il)isophthalate to rats with experimental cardiovascular pathology resulted in a shift of all indices studied to the control values that indicated the cardioprotective and antioxidant properties of the substance. In most cases the protective effect was dose-dependent. These data are interesting for the development of new approaches for therapy of rheumatoid arthritis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
