Abstract

Cardiometabolic syndrome (CMS) refers to the clustering of various metabolic and cardiovascular risk factors, including dysglycemia, dyslipidemia, hypertension, and obesity. Recent evidence suggests a strong relationship between CMS and the development of chronic kidney disease (CKD). Insulin resistance and compensatory hyperinsulinemia with its multiple deleterious effects is central to CMS and is thought to contribute to renal injury. In addition, hemodynamic factors, renal lipotoxicity, and inflammatory adipocytokines derived from visceral adipose tissue are thought to further contribute to renal injury in CMS. This review discusses the epidemiology of CMS and CKD, the pathophysiologic link between the two, and potential interventions to prevent renal injury.

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