Abstract
Our object in this study was to determine the effect of exercise on the cardiac output of several patients with heart disease. These patients were studied first under basal conditions, and the results were reported in paper I.1The group consisted of three patients with rheumatic valvular disease, one with subacute rheumatic fever, one with probable chronic myocarditis and two with complete heart block. In addition, control observations were made on four normal subjects, one of whom was obese. The effect of graded exercise (by means of the stationary bicycle) on the output of the heart in normal subjects has been reported by Krogh and Lindhard,1aMeans and Newburgh,2Boothby,3Collett and Liljestrand,4and Bock and his co-workers.5The earlier workers used the nitrous oxide method to determine the cardiac output, whereas Bock's observations were made with the modified Haldane method. The latter procedure, as described by Bock, Dill
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