Abstract
1. 1. The cardiac effects of the N-terminal (1–34) peptide fragment of bovine parathyroid hormone [bPTH-(1–34)] on isolated atria were examined in the frog, Rana tigrina. 2. 2. bPTH-(1–34) produced dose-related inotropic response but no chronotropic response. This inotropic response varied at different times of the year. 3. 3. The inotropic effect of bPTH-(1–34) was attenuated in the presence of verapamil and imidazole. 4. 4. The mechanism of action of bPTH-(1–34) is probably a stimulation of calcium influx directly or indirectly via cAMP production.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Comparative Biochemistry and Physiology. Part C, Comparative Pharmacology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
