Abstract
Tobacco smoke condensates (tars) from (1) cigarettes made from leaf which had received a field treatment of the organophosphate insecticide dimethoate (as the commercial formulation “Rogor 40”) at 5 times the normal dosage rate; and (2) cigarettes made from normal unsprayed leaf, have been compared for carcinogenic activity on mouse skin, in order to investigate the possibility of pyrolytic formation of carcinogenic products from insecticide residues. There was no difference between the two tars in their ability to produce skin tumours, tumour incidence and latent periods of induction being similar in both groups of mice. Neither was there any statistically significant difference between the groups of mice in the incidence of any other type of tumour. It is concluded that the treatment of tobacco plants with dimethoate (as “Rogor 40”) does not alter the mouse skin carcinogenicity of tobacco smoke condensate.
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