Abstract
Carcinogenic potency of 15 oils (petroleum distillates) was tested by repeated applications (with a dropper, approx. 50 mg of undiluted oil 2x/wk until appearance of papilloma, death of animal, or termination of experiment at 80 wk) to the skin of the interscapular region of male C3H/HeJ mice. Seven oils were carcinogenic and produced malignant tumors; another produced only benign tumors (2). None of 8 oils processed by solvent refining produced malignant tumors; hence this process appeared to remove carcinogens. Extraction by solvents such as phenol, cresol, or furfural appeared to be more effective in removing carcinogenic compounds from the oils than the conventional refining procedure. Sulfurization of 2 of the oils led to tumors after only 13 and 23 wk, indicating increased tumorigenic potency. The oils were analyzed for their content of 4- and 5-ring aromatic hydrocarbons but a definite correlation to carcinogenicity was not established with certainty.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
