The capture and suppression of irrelevant response tendencies: a TMS-DTI approach

Abstract

Event Abstract Back to Event The capture and suppression of irrelevant response tendencies: a TMS-DTI approach Dilene Van Campen1*, W.P.M. Van Den Wildenberg1 and K.R. Ridderinkhof1 1 University of Amsterdam, Netherlands Selective inhibitory control when selecting between two actions is an important aspect of goal-directed behavior. In the Simon task, participants respond to a relevant feature (circle color) while ignoring an irrelevant feature (circle location). The goal of the experiments is to link behavioral indices of top-down suppression of involuntary response impulses and response capture with physiological and anatomical markers.In three experiments we collected single pulse, repetitive Transcranial Magnetic Stimulation (spTMS and rTMS) and Diffusion Tensor Imaging (DTI) data. Behavioral data was assessed in all experiments, using RT distribution analyses and conditional accuracy functions (CAF). In the first experiment spTMS is applied over motor cortex at different timing moments to link behavioral indices of inhibition with physiological markers and to track its time course. In the second experiment DTI data was collected to link behavioral indices of inhibition with anatomical markers. In the third experiment 1hz offline rTMS was applied over the pre supplementary motor area (pre-SMA) and right inferior frontal gyrus (rIFG) to interfere with the function of the two cortical areas.The spTMS results showed an early increase in M1 activation indicative of response capture, followed by cortical inhibition on correct interference trials. DTI analyses suggested involvement of pre-SMA and rIFG. Preliminary data from the rTMS experiment point to more fast errors after pre-SMA stimulation, indicating impaired response selection. Secondly, rIFG stimulation seems to enhance interference effects, suggesting impaired selective suppression of irrelevant information. Keywords: decision-making, DTI Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Poster Sessions: Decision Making, Reward Processing & Response Selection Citation: Van Campen D, Van Den Wildenberg W and Ridderinkhof K (2011). The capture and suppression of irrelevant response tendencies: a TMS-DTI approach. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00364 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Nov 2011; Published Online: 28 Nov 2011. * Correspondence: Dr. Dilene Van Campen, University of Amsterdam, Amsterdam, Netherlands, a.d.vancampen@uva.nl Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Dilene Van Campen W.P.M. Van Den Wildenberg K.R. Ridderinkhof Google Dilene Van Campen W.P.M. Van Den Wildenberg K.R. Ridderinkhof Google Scholar Dilene Van Campen W.P.M. Van Den Wildenberg K.R. Ridderinkhof PubMed Dilene Van Campen W.P.M. Van Den Wildenberg K.R. Ridderinkhof Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.