Abstract
The etiology of psoriasis remains obscure. The primary site of involvement of tissues, namely, epidermis, dermis or vasculature is equally doubtful. This study was undertaken to elucidate, if possible, in which structure the first change in psoriasis can be localized. The present thoughts on this subject are well stated by Shelley and Arthur (1). Kuta and Neumann, (2) investigated changes in dehydrogenase activity in epidermal cells after trauma. They report that there is an increase in this enzyme activity in psoriasis earlier than any other observed change. The earliest biopsy study reported in this study was on the sixth day and it showed histologically only nonspecific acanthosis. Szodoray (3), reports on biopsy specimens taken at various time intervals after trauma to skin. His findings tend to place the earliest changes in psoriasis in the capillaries.
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