Abstract
The local-regional oncological hyperthermia has various electromagnetic methods for energy-transfer. The differences involve conceptual considerations and technical solutions. The most frequently applied energy transfer is capacitive coupling, concentrating the electric field to be the active heating component. The realization of the capacitive coupling set-up is divided into two different categories based on their goals for heating: 1) the homogeneous (conventional) heating, using isothermal conditions for dosing, and 2) the selective heterogeneous heating, using cellularly absorbed energy for dosing. The homogeneous heating utilizes plane-wave matching, absorbing the wave for energy transfer. The heterogenic heating uses impedance matching, selecting the malignant cells by their electromagnetic specialties, like their heterogenic impedance, higher membrane-raft density, and different spatio-temporal (pathologic pattern) arrangements. This article’s objective is to compare and discuss the details of the two kinds of capacitive coupling techniques.
Highlights
Strategy in the Fight against CancerLife is based on energetically open systems, where environmental conditions determine their equilibrium
The modulated electro-hyperthermia (mEHT) impedance-matched capacitive coupling has four interconnected mechanisms for selection: the heterogeneities in conductivity and dielectric permittivity select the tumor, and its independent, while the membrane rafts absorb the energy in selected cells, and the spatiotemporally distinguishable tumor-pattern provides an additional factor for selectivity, and isolation of the malignant cells, Figure 25
It is clear that mEHT produces the same 25% relative cell-death as homogeneous heating in ≈3 ̊C lower temperature, which is an approximate difference between the local nano-temperature and the tumor-average temperature
Summary
Life is based on energetically open systems, where environmental conditions determine their equilibrium. The first few attempts block the proliferation and start intracellularly controlling the DNA replication It fails for various reasons, including genetic aberration [4], mitochondrial dysfunction [5], or other intracellular [6], and extracellular [7] hallmarks of malignancy. The breaking of cellular networks is a general behavior of all tumors independent of their locations within the body In this sense, cancer is an organizing (networking) disease, where the cells unleashed from their networks abandon the living advantages of collectivism, and individualism prevails [8]. The proliferating cell actively changes its environment, forcing the healthy host to supply the needed materials [12]. The final aim of cancer treatments is to eliminate the cancer cells throughout the body
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
