Abstract

Abstract This chapter discusses all three aspects of canine models as they concern an example of a set of genes associated with disease in humans and dogs, and then proceeds to expand on the most salient features and examples of each these three aspects for other canine genetic diseases as models in medical genetics. Topics discussed are the identification of disease genes; analysis of gene function and disease pathogenesis; and the treatment of disease through supplements and pharmacological treatments, enzyme replacement, RNA treatment, bone marrow transplantation and gene therapy.

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