Abstract
BackgroundThe purpose of this study was to clarify the species of Candida that are important for the development of atrophic glossitis in xerostomia patients.MethodsA total of 231 patients with subjective dry mouth were enrolled in the present study. Logistic regression analysis was performed to clarify the contribution of each Candida species and other variables to the development of atrophic glossitis. The dependent variable was the absence/presence of atrophic glossitis. The Candida colony-forming units (CFU) of C. albicans, C. glabrata, C. tropicalis, and C. krusei, as well as age, gender, resting (RSFR) and stimulated (SSFR) whole salivary flow rate, and denture-wearing status, were treated as explanatory variables.ResultsLogistic regression analysis showed that two factors were closely associated with the presence of atrophic glossitis: an increase in C. albicans CFU and a decrease in the SSFR.ConclusionsC. albicans, but not non-albicans Candida, was associated with atrophic glossitis in xerostomia patients who had no systemic predisposing factors, indicating that C. albicans remains a treatment target for Candida-related atrophic glossitis.
Highlights
In addition to these variants, angular cheilitis, median rhomboid glossitis, and denture stomatitis have been recognized as Candida-associated lesions; Candida super-infection in oral lichen planus is frequently encountered
The purpose of this study was to clarify the species of Candida that are important for the development of atrophic glossitis in xerostomia patients
Study population Overall, atrophic glossitis was noted in 46 patients (Table 1), tongue redness in 58, palate redness in 16, buccal mucosa redness in 10, lip redness in 16 and angular cheilitis in 25
Summary
The purpose of this study was to clarify the species of Candida that are important for the development of atrophic glossitis in xerostomia patients. Oral candidiasis is sub-classified into three major variants: pseudomembranous, erythematous, and hypertrophic [1, 2]. In addition to these variants, angular cheilitis, median rhomboid glossitis, and denture stomatitis have been recognized as Candida-associated lesions; Candida super-infection in oral lichen planus is frequently encountered. The various forms of oral candidiasis are caused by interactions between the host defenses and fungal virulence factors. Atrophic glossitis is caused by complete or partial lingual papillary atrophy. It exhibits a smooth, glossy appearance with a red or pink background and is primarily a manifestation of an underlying condition.
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