Abstract
Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent regulator of innate and adaptive immune cell functions. Therapeutic strategies to interrupt or enhance cAMP generation or effects have immunoregulatory potential in autoimmune and inflammatory disorders. Here, we provide an overview of the cyclic AMP axis and its role as a regulator of immune functions and discuss the clinical and translational relevance of interventions with these processes.
Highlights
Cells must be able to sense and integrate countless extracellular and intracellular signals and adapt their cellular functions
This review aims to shed light on the variety of processes influenced by Cyclic adenosine monophosphate (cAMP) in the immune system with regard to treatment options in diseases
In the immune system extracellular cAMP may contribute to regulatory T cells (Treg) function [31, 32] and has been shown to promote monocyte differentiation into dendritic cells (DCs) [33]
Summary
Nucleotide signaling molecules contribute to the regulation of cellular pathways. Cyclic adenosine monophosphate (cAMP) is well established as a potent regulator of innate and adaptive immune cell functions. Therapeutic strategies to interrupt or enhance cAMP generation or effects have immunoregulatory potential in autoimmune and inflammatory disorders. We provide an overview of the cyclic AMP axis and its role as a regulator of immune functions and discuss the clinical and translational relevance of interventions with these processes. Reviewed by: Gottfried Baier, Medical University of Innsbruck, Austria Jacques A. Centre de Recherche en Cancerologie de Marseille, France
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