The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data repository: Structural and functional MRI, MEG, and cognitive data from a cross-sectional adult lifespan sample

Jason R Taylor,Nitin Williams,Rhodri Cusack,Tibor Auer,Meredith A Shafto,Marie Dixon,Lorraine K Tyler,Cam-Can Cam-Can,Richard N Henson

doi:10.1016/j.neuroimage.2015.09.018

Abstract

This paper describes the data repository for the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) initial study cohort. The Cam-CAN Stage 2 repository contains multi-modal (MRI, MEG, and cognitive-behavioural) data from a large (approximately N=700), cross-sectional adult lifespan (18–87years old) population-based sample. The study is designed to characterise age-related changes in cognition and brain structure and function, and to uncover the neurocognitive mechanisms that support healthy cognitive ageing. The database contains raw and preprocessed structural MRI, functional MRI (active tasks and resting state), and MEG data (active tasks and resting state), as well as derived scores from cognitive behavioural experiments spanning five broad domains (attention, emotion, action, language, and memory), and demographic and neuropsychological data. The dataset thus provides a depth of neurocognitive phenotyping that is currently unparalleled, enabling integrative analyses of age-related changes in brain structure, brain function, and cognition, and providing a testbed for novel analyses of multi-modal neuroimaging data.

Highlights

OverviewThe Cambridge Centre for Ageing and Neuroscience (Cam-CAN) Stage 2 cohort study is a large-scale
This paper describes the data repository for the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) initial study cohort
Taylor et al / NeuroImage 144 (2017) 262–269 anisotropy measures from the diffusion-weighted (DWI) MRI data with volumetric measures from the T1-weighted MRI data to show that white matter (WM) and grey matter (GM) in frontal cortex make independent contributions to age-related declines in fluid intelligence and multitasking

Summary

Overview

The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) Stage 2 cohort study is a large-scale Stage 2 includes a wide range of neuroimaging measures: high-resolution (1 mm3) T1- and T2-weighted images, diffusion-weighted images (DWI), magnetisation-transfer (MT) images, and BOLD EPI images during rest, a sensorimotor task and movie-watching, as well as MEG data during rest and the same sensorimotor task. The depth of this neurocognitive phenotyping is currently unparalleled, and provides a testing ground for the development of new multimodal analysis methods.

Data-collection stages

Purpose

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Summary