Abstract
Abstract In vitro studies of the canine basilar artery have demonstrated that calmodulin antagonism can effectively inhibit cerebral arterial smooth muscle contractility. The prophylactic and therapeutic effectiveness of a potent calmodulin antagonist. the phenothiazine compound tnfluoperazine (TFP). was investigated in vivo over a wide range of doses in the well-documented “double-subarachnoid hemorrhage” canine model of cerebral vasospasm. The compound is perhaps more well-known under its trade name. Stelazine. as a classic antipsychotic drug. The drug demonstrated no therapeutic relief of preexisting chronic cerebral vasospasm at any time during 2 days of systemic administration at any practical dose. At doses far in excess of the normally accepted therapeutic range in humans. a prophylactic regimen reduced the severity of chronic cerebral vasospasm after subarachnoid hemorrhage by approximately 35% compared to untreated dogs.
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