Abstract
A number of lignans, including those isolated from Arctium lappa (Compositae), were subjected to Ca2+ antagonist assay. The most potent activity occurred in trachelogenin, the calculated Ic50 and pA2 of which were 1.1×10-6 M and 6.60 respectively. Tranchelogenin had a potent and long-lasting antihypertensive effect on spontaneously hypertensive rats.
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