Abstract
Background. Functional dyspepsia (FD) is a functional upper gastrointestinal disorder with significant morbidity and medical costs. Previous studies investigated the association of G-protein β3 (GNB3) genetic polymorphisms with FD but with inconsistent results. Therefore, we performed a meta-analysis to derive a precise estimation of the relationship between GNB3 polymorphisms and FD. Methods. We searched different databases including PubMed, EMBASE, CNKI, and the Ovid Library to gather eligible studies on GNB3 polymorphisms and FD. The association was assessed by the odds ratio (OR) with 95% confidence intervals (CI). Results. We identified 12 studies with 1109 cases and 2853 controls for the analysis. We found no associations of GNB3 C825T polymorphism with FD in the overall population (T versus C, OR = 1.06, 95% CI: 0.96–1.18, P = 0.26; TT versus CC + CT, OR = 1.16, 95% CI: 0.97–1.39, P = 0.11; TT + CT versus CC, OR = 1.01, 95% CI: 0.77–1.31, P = 0.96; TT versus CC, OR = 1.15, 95% CI: 0.93–1.44, P = 0.20). Subgroup analyses by genotyping method indicated that the magnitude of association was strengthened for additive model (OR = 1.15, 95% CI: 1.07–2.24, P = 0.02). Sensitivity analysis did not reveal significant associations under all models. Conclusions. This meta-analysis demonstrates that GNB3 C825T polymorphism may not be a risk factor for FD.
Highlights
Functional dyspepsia is one of the most common chronic gastrointestinal disorders encountered in clinical practice [1], with prevalence up to 40% and annual incidence ranging from 1% to 6% in population-based studies, respectively [2,3,4,5]
To search for all the studies investigating the association of the GNB3 polymorphism with Functional dyspepsia (FD) risk, we conducted a systematic computerized literature search from PubMed, EMBASE, the Ovid Library, and the Chinese National Knowledge Infrastructure (CNKI) prior to March 2015 using the following keywords and subject terms: “functional dyspepsia” or “FD,” “G-protein beta3” or “GNB3,” “mutation,” “variant,” and “polymorphism.” The full text of the retrieved articles was scrutinized to inspect whether information on the topic of interest was included
Our initial literature search yielded 85 published studies, of which 63 studies were excluded for not investigating the association of GNB3 C825T polymorphism with FD after screening titles and abstracts
Summary
Functional dyspepsia is one of the most common chronic gastrointestinal disorders encountered in clinical practice [1], with prevalence up to 40% and annual incidence ranging from 1% to 6% in population-based studies, respectively [2,3,4,5]. Both in uninvestigated dyspepsia in the general population and in patients with functional dyspepsia who are seen in tertiary-care settings, the most typical dyspeptic symptoms include postprandial fullness, upper abdominal bloating, epigastric pain, and early satiation, often accompanied by other upper gastrointestinal symptoms such as nausea, belching, or epigastric burning. This meta-analysis demonstrates that GNB3 C825T polymorphism may not be a risk factor for FD
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