Abstract
The 5HT1A receptor is one of at least 14 different receptors for serotonin which has a role in moderating several brain functions and may be involved in the aetiology of several psychiatric disorders. The C(-1019)G 5-HT1A promoter polymorphism was reported to be associated with major depression, depression-related personality traits and suicidal behavior in various samples. The G(-1019) allele carriers are prone to depressive personality traits and suicidal behavior, because serotonergic neurotransmission is reduced.The aim of this study is to replicate previous findings in a sample of 185 Alcohol-dependent individuals. Personality traits were evaluated using the NEO FFI and TCI. History of suicidal behavior was assessed by a standardized semistructured interview (SSAGA). No significant differences across C(-1019)G 5-HT1A genotype groups were found for TCI temperament and character traits and for NEO FFI personality scales. No association was detected between this genetic variant and history of suicide attempts. These results neither support a role of C(-1019)G 5-HT1A promoter polymorphism in the disposition of personality traits like harm avoidance or neuroticism, nor confirm previous research reporting an involvement of the G allele in suicidal behavior in alcoholics. Significant associations, however, were detected between Babor's Type B with number of suicide attempts in history, high neuroticism and harm avoidance scores in alcoholics.
Highlights
The 5-hydroxytryptamine 1A receptor (5-HT1A) is one of several different receptors for 5-hydroxytryptamine
The aim of our study is to investigate the C(-1019)G 5HT1A-promoter polymorphism and its possible association with anxiety and depression-related personality traits and suicidal behavior
Using a single MANOVA no significant association was detected between C(-1019)G 5-HT1A and suicide attempt in history (F = 0.230, p = 0.795, df = 2), between C(1019)G 5-HT1A and neuroticism (F = 0.811, p = 0.446, df = 2) and between C(-1019)G 5-HT1A and harm avoidance (F = 0.268, p = 0.765, df = 2)
Summary
The 5-hydroxytryptamine 1A receptor (5-HT1A) is one of several different receptors for 5-hydroxytryptamine (serotonin). Evidence for a role of 5-HT1A receptor in the pathophysiology of anxiety and depression has come from several clinical studies as well as from animal models [1,2,3]. 5-HT1A receptor-deficient animals have been reported to have an increased level of anxiety and stress response as well as decreased exploratory activity [4,5]. The 5-HT1A receptor is suggested to be involved in the response to antidepressant and anxiolytic drugs [6,7]. The 5-HT1A receptor is an integral membrane protein and belongs to the family of G-protein coupled receptors that inhibit adenylate cyclase activity.
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