Abstract
This study used the Korean National Health Insurance (NHI) claims database from 2011 to 2017 to estimate the incidence and the incidence-based cost of cervical cancer and carcinoma in situ of cervix uteri (CIS) in Korea. The primary outcome was the direct medical cost per patient not diagnosed with cervical cancer (C53) or CIS (D06) 2 years prior to the index date in the first year after diagnosis. A regression analysis was conducted to adjust for relevant covariates. The incidence of cervical cancer tended to decrease from 2013 to 2016, while that of CIS increased. In particular, the incidence rate of CIS in women in their 20 s and 30 s increased by 56.8% and 28.4%, respectively, from 2013 to 2016. The incidence-based cost of cervical cancer and CIS was USD 13,058 and USD 2695 in 2016, respectively, which increased from 2013. Multivariate regression analysis suggested that age was the most influential variable of the cost in both patient groups, and the cost was highest in those aged over 60, i.e., the medical cost was significantly lower in younger women than their older counterparts. These findings suggest that targeting younger women in cervical cancer prevention is a reasonable option from both economic and public health perspectives.
Highlights
IntroductionCervical cancer is the fourth most widespread cancer, with an estimated 569,800 new cases in 2018
Cervical cancer is the fourth most widespread cancer, with an estimated 569,800 new cases in 2018.It is one of the leading causes of female death worldwide, with 80% of all deaths occurring in Africa and Southwest Asia [1]
With regard to cervical cancer patients, the mean medical cost was similar in the age groups >40 years; the medical cost of both patient groups was statistically different according to age in each year
Summary
Cervical cancer is the fourth most widespread cancer, with an estimated 569,800 new cases in 2018. It is one of the leading causes of female death worldwide, with 80% of all deaths occurring in Africa and Southwest Asia [1]. Cervical cancer is preventable because it takes several years to develop, which allows detection at early stages of the disease [3]. Cervical cancer is a sexually transmitted disease (STD) caused by human papillomavirus (HPV) infection. Known risk factors for cervical cancer include young age at first sexual intercourse, smoking, and low economic status [4]. Continuous infection with HPV can lead to abnormal proliferation of the cervical epithelium and development of cervical intraepithelial neoplasia (CIN).
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