Abstract
ABSTRACT.We performed a 2-year prospective cohort study to determine the incidence of dengue in Angoda, Colombo district, Sri Lanka (NCT02570152). The primary objective was to determine the incidence of acute febrile illness (AFI) because of laboratory confirmed dengue (LCD). Secondary objectives were to determine AFI incidence because of non-LCD, describe AFI symptoms, and estimate AFI incidence because of LCD by dengue virus (DENV)-type and age group. Participants from households with at least one minor and one adult (≤50 years) were enrolled and followed with scheduled weekly visits and, in case of AFI, unscheduled visits. Blood was collected for DENV detection at AFI visits, and symptoms recorded during the 7-day period following AFI onset. A total of 2,004 participants were enrolled (971 children, and 1,033 adults). A total of 55 LCD episodes were detected (overall incidence of 14.2 per 1,000 person-years). Incidence was the highest among children < 5 years (21.3 per 1,000 person-years) and 5–11 years (22.7 per 1,000 person-years), compared with adults ≥ 18 years (9.2 per 1,000 person-years). LCD was mostly (83.6%) caused by DENV-2 (n = 46), followed by DENV-1 (n = 6) and DENV-3 (n = 3). Common symptoms of LCD were headache, fatigue, myalgia, loss of appetite, and arthralgia. Incidence of AFI because of non-LCD was 47.3 per 1,000 person-years. In conclusion, this study reports the LCD incidence for a DENV-2 dominated epidemic that is comparable to the incidence of suspected dengue reported passively for 2017, one of the worst outbreaks in recent history.
Highlights
Dengue is an arboviral illness caused by one of four different serotypes of infecting virus
A total of 15 participants were withdrawn: two participants because of noncompliance with protocol requirements; and 13 participants because they moved from the study area (Table 1)
Of the 183 episodes of acute febrile illness (AFI) because of non-laboratory confirmed dengue (LCD), seven (3.8%) episodes resulted in hospitalization, three (1.6%) episodes in the, 5 years of age group, three (1.6%) episodes in the 5–11 years of age group, and one (0.5%) episode in the adult group (Supplemental Table 9). This prospective 2-year cohort study conducted in the Colombo district of Sri Lanka detected an incidence of LCD of 14.2 per 1,000 person-years in the total study population, consisting of adults and children
Summary
Dengue is an arboviral illness caused by one of four different serotypes of infecting virus (dengue virus [DENV]-1, DENV-2, DENV-3, and DENV-4). Symptoms of DENV infection include fever, headache, skin erythema, arthralgia, and myalgia, which are common symptoms of other febrile illnesses; misdiagnosis and underreporting are common. Dengue is the most important mosquito-borne viral disease globally, of which the incidence has increased 30-fold during the past five decades.[1] Geographically, half the world’s population is at risk of DENV infection, and it was estimated that in 2013, globally, 58.4 (uncertainty interval 23.6–121.9) million people were infected.[2] the disease’s exact distribution is uncertain, dengue is found in tropical and subtropical climates, mostly in urban and semiurban areas.[3] According to the World Health Organization (WHO), an estimated 100 countries are affected,[4] there is strong evidence for dengue occurrence in 128 countries.[5] About 70.0% of the disease burden is in Asia.[6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The American Journal of Tropical Medicine and Hygiene
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
