Abstract
The buffering of the blood during hypoxaemia and during respiratory exchange in the lungs and in the tissues is considered in the presence of factors known to influence the in vivo buffering of CO 2 alone. It is argued that during systemic hypoxaemia or asphyxia the Haldane effect in the circulating blood has a smaller value than it has in vitro, but during respiratory exchange in the lungs and in the tissues, the Haldane effect retains its full in vitro value. Changes in arteriovenous differences can be shown to appear to alter the acid-base characteristics of the arterial blood. It is concluded that the in vivo CO 2 dissociation curve is the dissociation curve of mixed venous blood and that the arterial blood is related to the mixed venous blood through the in vitro dissociation curve.
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