Abstract

The evolution of the field of neuroscience has been propelled by the advent of novel technological capabilities, and the pace at which these capabilities are being developed has accelerated dramatically in the past decade. Capitalizing on this momentum, the United States launched the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative to develop and apply new tools and technologies for revolutionizing our understanding of the brain. In this article, we review the scientific vision for this initiative set forth by the National Institutes of Health and discuss its implications for the future of neuroscience research. Particular emphasis is given to its potential impact on the mapping and study of neural circuits, and how this knowledge will transform our understanding of the complexity of the human brain and its diverse array of behaviours, perceptions, thoughts and emotions.

Highlights

  • The human brain is the most complex biological entity in the known universe and understanding how it works—that is, how its molecules, cells, circuits and systems enable behaviour, perception, thought and emotion—is the overarching goal of& 2015 The Authors

  • We review the scientific vision for this initiative set forth by the National Institutes of Health and discuss its implications for the future of neuroscience research

  • Particular emphasis is given to its potential impact on the mapping and study of neural circuits, and how this knowledge will transform our understanding of the complexity of the human brain and its diverse array of behaviours, perceptions, thoughts and emotions

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Summary

Introduction

The human brain is the most complex biological entity in the known universe and understanding how it works—that is, how its molecules, cells, circuits and systems enable behaviour, perception, thought and emotion—is the overarching goal of. Given the audacious nature of this goal, the President called for the BRAIN Initiative to be an ‘all hands on deck’ effort involving agencies within the United States government, and companies, health systems, patient advocacy organizations, philanthropists, state governments, research universities, private research institutes, scientific societies and more. The envisioned long-term pay-off of the BRAIN Initiative is a more comprehensive understanding of how the brain produces complex thoughts and behaviours that will provide an essential guide to progress in diagnosing, treating and potentially curing neurological and psychiatric diseases and disorders that devastate so many lives. We provide a synopsis of our final report to the NIH, aiming to convey succinctly both the substance and the excitement of our journey

The BRAIN Initiative: charting the course
BRAIN 2025: a scientific vision
Priority research areas
12. Core principles of the BRAIN Initiative
13. Concluding remarks
Methods
19. Ugurbil K et al 2013 Pushing spatial and temporal
24. Chung K et al 2013 Structural and molecular
82. Schuepbach WM et al 2013 Neurostimulation for
Full Text
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