Abstract
Yiping Lu et al. [1] report increased grey matter volumes and changes in MRI-based measures of water diffusion in white matter in the brains of recovered COVID-19 patients three months after acute illness, compared to healthy controls. They propose that neurogenesis and hypertrophy caused volumetric enlargement, and pathway remyelination restricted diffusion in the patients. If valid, these explanations suggest vigorous and counter-intuitive compensatory brain mechanisms during recovery from COVID-19.
Highlights
Yiping Lu et al [1] report increased grey matter volumes and changes in MRI-based measures of water diffusion in white matter in the brains of recovered COVID-19 patients three months after acute illness, compared to healthy controls. They propose that neurogenesis and hypertrophy caused volumetric enlargement, and pathway remyelination restricted diffusion in the patients
Dr Fieremans reports personal fees from General Electric Company, other from MicSi, Inc., outside the submitted work
Summary
The brain after COVID-19: Compensatory neurogenesis or persistent neuroinflammation?. Sodicksonc, Els Fieremansd a Department of Neurology, NYU Grossman School of Medicine, 315 West 57th Street, Suite 401, New York, NY 10019, USA b Stanley H. Appel Department of Neurology, Houston Methodist and Weill Cornell Medical College, 6560 Fannin Street, Suite 1840, Houston, TX 77030 USA c Department of Radiology, NYU Grossman School of Medicine, 660 First Avenue, Fourth Floor, Room 407, New York, NY 10016, USA d Department of Radiology, NYU Grossman School of Medicine, 660 First Ave. 2nd floor, 205, New York City, NY 10016, USA
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